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| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Human prothrombin complex (Sinopharm Shanghai Plasma) | Approved | Sinopharm Shanghai Plasma-Derived Biotherapies Co Ltd | Mainland China | Hemorrhage | Sinopharm Shanghai Plasma-Derived Biotherapies Co Ltd | 1997-01-01 | Hemorrhage | Details | ||
| Prothrombinex-VF (CSL Behring) | Approved | Csl Behring Llc | Australia | Hemorrhage | Csl Behring Llc | 2014-10-01 | Hemorrhage | Details | ||
| Human prothrombin complex (Shanghai Xinxing) | Approved | Shanghai Xinxing Medicine Co Ltd | Mainland China | Hemorrhage | Shanghai Xinxing Medicine Co Ltd | 1997-01-01 | Hemorrhage | Details | ||
| Human prothrombin complex concentrate (Guizhou Taibang Biological Products) | Approved | Guizhou Taibang Biological Products Co Ltd | Mainland China | Hypoprothrombinemias | Guizhou Taibang Biological Products Co Ltd | 2013-07-31 | Hypoprothrombinemias | Details | ||
| Human Antithrombin III (Hemarus Therapeutics) | Approved | Hemarus Therapeutics | India | Antithrombin III Deficiency | Hemarus Therapeutics | 2015-08-01 | Antithrombin III Deficiency | Details | ||
| Dabigatran etexilate | Approved | Details | ||||||||
| Human prothrombin complex (Tonrol Biopharmaceuticals) | Approved | ProthoRAAS | Mainland China | Hemorrhage | Shanghai Raas Blood Products Co Ltd | 1996-01-01 | Hemophilia B; Hemorrhage | Details | ||
| Glucosamine Hydrochloride/Dermatan sulfate | Approved | Details | ||||||||
| Hirudin biosimilar (Rhein-Minapharm) | Approved | Rhein Minapharm Biogenetics | Thrombexx | Egypt | Venous Thrombosis | Rhein Minapharm Biogenetics | 2006-10-01 | Venous Thrombosis | Details | |
| Enoxaparin sodium biosimilar (Chandra Bhagat Pharma) | Approved | Chandra Bhagat Pharma（Cbc） | MAXIPARINE | Venous Thrombosis | Details | |||||
| Enoxaparin sodium biosimilar (Harvest Moon Pharmaceuticals) | Approved | Harvest Moon | Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Venous Thrombosis | Details | ||||||
| Enoxaparin sodium biosimilar (Sahar International Trading) | Approved | Sahar International Trading | Angina, Unstable; ST Elevation Myocardial Infarction; Venous Thromboembolism; Blood Coagulation Disorders | Sahar International Trading | 2013-07-01 | Blood Coagulation Disorders; Angina, Unstable; ST Elevation Myocardial Infarction; Venous Thromboembolism | Details | |||
| Heparin sodium biosimilar (Blau Pharmaceuticals) | Approved | Blau Pharmaceuticals | Hepamax-S | Brazil | Thrombosis | Blau Pharmaceuticals | 2012-08-01 | Thrombosis | Details | |
| Enoxaparin sodium biosimilar (Blau Pharmaceuticals) | Approved | Blau Pharmaceuticals | Enoxalow | Thrombosis | Blau Pharmaceuticals | 2013-07-01 | Thrombosis | Details | ||
| Ardeparin sodium | Approved | Wyeth-Ayerst | Normiflo | United States | Pulmonary Embolism; Venous Thrombosis | null | 1997-05-01 | Pulmonary Embolism; Venous Thrombosis | Details | |
| Enoxaparin sodium biosimilar (Neiss Labs) | Approved | Neiss Labs | Lomonox | India | Venous Thrombosis | Neiss Labs | 2012-08-01 | Venous Thrombosis | Details | |
| Enoxaparin sodium biosimilar (PT Kalbe) | Approved | Kalbe Farma | Kalbenox | Cambodia | Angina, Unstable; Myocardial Infarction; Venous Thrombosis | Kalbe Farma | 2012-01-01 | Angina, Unstable; Myocardial Infarction; Venous Thrombosis | Details | |
| Heparin sodium biosimilar (Chandra Bhagat Pharma) | Approved | Chandra Bhagat Pharma（Cbc） | Thromboparin | India | Thrombosis | Chandra Bhagat Pharma（Cbc） | 2012-08-01 | Thrombosis | Details | |
| Enoxaparin sodium biosimilar (Apotex Pty Ltd) | Approved | Apotex | Australia | Myocardial Ischemia; Angina, Unstable; Venous Thromboembolism; Thrombosis; Venous Thrombosis | Apotex | 2020-02-10 | Myocardial Ischemia; Angina, Unstable; Venous Thromboembolism; Venous Thrombosis; Thrombosis | Details | ||
| Enoxaparin sodium biosimilar (Gland Pharma) | Approved | Gland Pharma Ltd | Cutenox | Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Venous Thrombosis | Gland Pharma | 2014-10-01 | Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Venous Thrombosis | Details | ||
| Human prothrombin complex (Boya Bio-Pharmaceutical) | Approved | Mainland China | Hemorrhage | Boya Bio-Pharmaceutical Group Co Ltd | 2020-12-02 | Hemorrhage | Details | |||
| Human prothrombin complex (Guangdong Wellen) | Approved | Guangdong Wellen Pharmaceutical Co Ltd | Mainland China | Hemorrhage | Guangdong Wellen Pharmaceutical Co Ltd | 2020-10-21 | Hemophilia B; Hemorrhage | Details | ||
| Antithrombin III (CSL Behring) | BI51.017 | Approved | Csl Behring Llc | Kybernin, Anthrobin, Athimbin | Japan | Thrombosis; Disseminated Intravascular Coagulation | Csl Behring Llc | 1987-08-02 | Disseminated Intravascular Coagulation; Thrombosis | Details |
| Human prothrombin complex concentrate (Shanxi Kangbao Biological Products) | Approved | Shanxi Kangbao Biological Product Co Ltd | Mainland China | Hemorrhage | Shanxi Kangbao Biological Product Co Ltd | 2019-09-17 | Hemophilia B; Hemorrhage | Details | ||
| Human prothrombin complex(Hebei Daan Pharmaceutical) | Approved | Hebei Daan Pharmaceutical Co Ltd | Mainland China | Hemorrhage | Hebei Daan Pharmaceutical Co Ltd | 2020-01-01 | Hemophilia B; Hemorrhage | Details | ||
| Human prothrombin complex (Nanyue Biopharming) | Approved | Hunan Ziguang Huhan Nanyue Pharmaceutical Co Ltd | Mainland China | Hemorrhage | Hunan Ziguang Huhan Nanyue Pharmaceutical Co Ltd | 2019-09-05 | Hemophilia B; Hemorrhage | Details | ||
| Thrombomodulin Alfa | ART-123; TMD-123; AT-908 | Approved | Asahi Kasei Corp | Recomodulin | Japan | Disseminated Intravascular Coagulation | Asahi Kasei Corp | 2008-01-25 | Disseminated Intravascular Coagulation | Details |
| Fibrinogen (Octapharma) | Approved | Octapharma | Fibryga, Fibryna | United States | Afibrinogenemia | null | 2017-06-07 | Afibrinogenemia | Details | |
| Liquid fibrin sealant (OMRIX Biopharmaceuticals) | Approved | Omrix Biopharmaceuticals | Quixil, Evicel | United States | Hemorrhage | null | 2003-03-21 | Hemorrhage | Details | |
| Antithrombin Gamma | KW-3357 | Approved | Kyowa Hakko Kirin Co Ltd | Acoalan | Japan | Antithrombin III Deficiency; Disseminated Intravascular Coagulation | Kyowa Hakko Kirin Co Ltd | 2015-07-03 | Disseminated Intravascular Coagulation; Antithrombin III Deficiency | Details |
| Factor IX complex (Grifols) | Approved | Grifols Sa | Profilnine | United States | Hemophilia B | null | 1981-07-21 | Intracranial Hemorrhages; Hemophilia B | Details | |
| Human prothrombin complex (Hualan Biological Engineering) | Approved | Hualan Genetic Engineering Co Ltd | Mainland China | Blood Coagulation Disorders | null | 1999-01-01 | Blood Coagulation Disorders; Hemophilia B; Factor X Deficiency | Details | ||
| Certoparin sodium | Approved | Novartis Pharma Ag | Troparin, Alphaparin, Sandoparin, Sandoparine, Mono-Embolex | Switzerland, Austria, India | Thromboembolism; Venous Thrombosis; Pulmonary Embolism | Aspen Pharma | 1997-01-01 | Pulmonary Embolism; Embolism; Renal Insufficiency; Thromboembolism; Uremia; Atrial Fibrillation; Venous Thrombosis; Kidney Failure, Chronic | Details | |
| Dermatan sulfate | MF-701; MF-777 | Approved | Mediolanum Farmaceutici Spa | Mistral | Italy | Venous Thromboembolism; Thrombosis; Thrombocytopenia | Mediolanum Farmaceutici Spa | 1998-07-01 | Venous Thromboembolism; Thrombocytopenia; Thrombosis | Details |
| Idarucizumab | 97RWB5S1U6 (UNII code); BI-655075 | Approved | Boehringer Ingelheim Gmbh | 泰毕安, Praxbind, Prizbind | Mainland China | Hemorrhage | Boehringer Ingelheim International Gmbh | 2015-10-16 | Hemorrhage | Details |
| Enoxaparin sodium biosimilar (Rovi) | Approved | Rovi | Arovi | Angina, Unstable; Myocardial Infarction; Venous Thrombosis | Rovi | 2018-03-31 | Angina, Unstable; Myocardial Infarction; Venous Thrombosis | Details | ||
| Human fibrinogen/Human thrombin (Baxalta) | Approved | Baxalta Incorporated | Tisseel | United States | Hemorrhage | null | 1998-05-01 | Seizures; Ecchymosis; Cerebrospinal Fluid Leak; Hemorrhage; Blepharoptosis | Details | |
| Fondaparinux Sodium | GSK-576428; Org-31540; SR-90107; SR-90107A | Approved | Organon | Arixtra, Quixidar, 安卓 | Japan | Pulmonary Embolism | Glaxosmithkline Plc | 2001-12-07 | Liver Diseases; Uterine Cervical Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Venous Thrombosis; Coronary Disease; Sarcoma; Atrial Fibrillation; Vulvar Neoplasms; Angina Pectoris; Ovarian Neoplasms; Thromboembolism; Neoplasms; Obesity, Morbid; Renal Insufficiency; Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Vaginal Neoplasms; Pulmonary Embolism | Details |
| Human prothrombin complex (LFB) | Approved | Lfb Biotechnologies Sas | KANOKAD | France | Hemorrhage | Lfb Biotechnologies Sas | 2008-09-01 | Hemorrhage | Details | |
| Parnaparin sodium | OP-2123; CB-01-05 | Approved | Opocrin Spa, Alfasigma Spa | Fluxum, Lowhepa, Minidalton | Portugal | Thrombosis | Alfasigma Usa Inc | 1993-01-01 | Thrombophlebitis; Infertility; Thrombosis | Details |
| Anti-inhibitor coagulant complex (Baxalta) | Approved | Baxalta Incorporated | Feiba, Prothromplex TOTAL | Japan | Hemophilia A; Hemophilia B | Baxalta Incorporated | 1979-12-21 | Blood Coagulation Disorders; Hemophilia A; Blood Coagulation Disorders, Inherited; Hemophilia B; Cardiovascular Diseases | Details | |
| Polysulfonic mucopolysaccharide | M-118102; M-1180B; M-7040B | Approved | Maruho Co Ltd | 喜辽妥, 喜疗妥 | Japan | Thrombophlebitis; Arthritis; Cicatrix; Chilblains | Maruho Co Ltd | 1954-10-01 | Thrombophlebitis; Cicatrix; Chilblains; Arthritis | Details |
| Antithrombin III (Octapharma Ab) | Approved | Octapharma Ab | Atenativ | EU | Antithrombin III Deficiency | Octapharma Ab | 2007-12-20 | Antithrombin III Deficiency | Details | |
| Fibrin patch (Ethicon/Omrix Biopharmaceuticals) | Approved | Johnson & Johnson | Evarrest | United States | Hemorrhage | null | 2012-12-05 | Peripheral Vascular Diseases; Gastrointestinal Diseases; Hemorrhage; Cardiovascular Diseases; Blood Loss, Surgical; Osteoarthritis | Details | |
| Dabigatran Etexilate Mesylate | BIBR-1048MS; BIBR-953-ZW; BIBR-1048; WD-1602; BIBR-953 | Approved | C.H. Boehringer Sohn Ag & Co. Kg | Pradaxa, Prazaxa, 泰毕全, Pradax, Rendix | United States | Venous Thromboembolism | Boehringer Ingelheim Pharmaceuticals Inc | 2008-03-17 | Atrial Fibrillation; Kidney Failure, Chronic; Renal Insufficiency, Chronic; Venous Thrombosis; Cardiovascular Diseases; Hepatic Insufficiency; Cognitive Dysfunction; Alzheimer Disease; Ischemic Attack, Transient; Coronary Disease; Embolism; Lung Diseases, Interstitial; Stroke; Thromboembolism; Scleroderma, Systemic; Heart Valve Diseases; Renal Insufficiency; Venous Thromboembolism; Pulmonary Embolism; Blood Coagulation Disorders | Details |
| Human prothrombin complex (CSL Behring) | BE-1116 | Approved | Csl Behring Llc | Kcentra, Beriplex, Confidex | Coagulation Protein Disorders; Blood Coagulation Disorders; Heart Failure; Heart Diseases; Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Wounds and Injuries | Details | ||||
| Argatroban | GN1600; MD-805; OM-805; DK-7419; MDI-805; MCI-9038 | Approved | Pfizer Pharmaceuticals Ltd (China), Mitsubishi Tanabe Pharma Corp | Acova, Argatra, Exembol, Slonnon, Novastan, Argatroban | United States | Thrombocytopenia | Accord Healthcare Inc | 1990-01-23 | Brain Ischemia; Venous Thromboembolism; Stroke; Hemorrhage; Genital Neoplasms, Female; Thrombocytopenia; Postoperative Complications; Adenocarcinoma; Thrombosis | Details |
| Bivalirudin | BG-8967; Hirulog-1 | Approved | The Medicines Company | Angiox, Kangio, Angiomax, Hirulog (former TM) | United States | Thrombosis | Maia Pharms Inc | 2000-12-15 | Carotid Artery Diseases; Myocardial Infarction; Angina, Unstable; ST Elevation Myocardial Infarction; Heart Diseases; Hemorrhage; Thromboembolism; Acute Disease; Acute Coronary Syndrome; Cardiovascular Diseases; Thrombocytopenia; Venous Thrombosis; Thrombosis; Subarachnoid Hemorrhage | Details |
| Human prothrombin complex (Octapharma) | Approved | Octapharma | Ocplex, Octaplex, Pronativ | United Kingdom | Hemorrhage | Octapharma | 2003-03-14 | Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| Prothrombin complex concentrate (Sanquin) | Approved | Sanquin Plasma Products Bv | Cofact | Hemorrhage | Sanquin Plasma Products Bv | 2007-11-01 | Hemorrhage | Details | ||
| Enoxaparin Sodium | PK-10169; PRY-005; XRP-4563K; M-enoxaparin; RPY-005; RP-54563 | Approved | Sanofi | Klexane, 克赛, Lovenox, Clexane, Enoxamed | EU | Venous Thromboembolism; Angina, Unstable; Non-ST Elevated Myocardial Infarction; Venous Thrombosis; Pulmonary Embolism | Techdow Pharma Netherlands Bv | 1993-03-29 | Fetal Growth Retardation; Colonic Neoplasms; Virus Diseases; Embolism and Thrombosis; Acute Coronary Syndrome; Hypoxia; Coronary Disease; Pre-Eclampsia; Coronavirus Infections; Pancreatic Neoplasms; Nephrotic Syndrome; Venous Thrombosis; Lung Neoplasms; Obstetric Labor, Premature; Thrombosis; Non-ST Elevated Myocardial Infarction; Carcinoma, Non-Small-Cell Lung; Catheter-Related Infections; Venous Thromboembolism; Pulmonary Embolism; Ovarian Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Myocardial Infarction; Angina, Unstable; ST Elevation Myocardial Infarction; Abdominal Neoplasms; Myocardial Ischemia; Pain; Brain Injuries, Traumatic; Coronavirus Disease 2019 (COVID-19); Neoplasms; Hip Fractures; Kidney Diseases; Obesity, Morbid | Details |
| Dalteparin Sodium | FR-860; KV-165; KABI-2165 | Approved | Pfizer Pharmaceuticals Ltd (China) | 法安明, Fragmin | Mainland China | Coronary Artery Disease; Thrombosis | null | 1985-01-01 | Prostatic Neoplasms; Anemia, Sickle Cell; Low Back Pain; Thrombosis; Kidney Failure, Chronic; Thrombophilia; Lung Neoplasms; Pregnancy Complications; Colorectal Neoplasms; Atrial Fibrillation; Brain Neoplasms; Breast Neoplasms; Hepatic Veno-Occlusive Disease; Diabetic Foot; Abortion, Habitual; Thromboembolism; Stroke; Central Nervous System Neoplasms; Coronary Artery Disease; Brain Injuries, Traumatic; Angina, Unstable; Myocardial Infarction; Venous Thromboembolism; Ovarian Neoplasms; Pulmonary Embolism | Details |
| Human coagulation factor X (Bio Products Laboratory) | Approved | Bio Products Laboratory Ltd | Coagadex | EU | Factor X Deficiency | Bpl Bioproducts Laboratory Gmbh | 2015-10-20 | Factor X Deficiency | Details | |
| Danaparoid sodium | KB-101; Org-10172 | Approved | Merck Sharp & Dohme Corp, Organon | Orgaran, Lomoparan | Japan | Venous Thromboembolism; Thrombocytopenia | Rubin Ltd | 1991-01-01 | Venous Thromboembolism; Venous Thrombosis; Thrombocytopenia | Details |
| Fibrin sealant patch (Takeda) | Approved | Nycomed Pharmaceutical | TachoSil, TachoComb | EU | Hemorrhage | null | 2004-06-08 | Cerebrospinal Fluid Leak; Liver Diseases; Lung Diseases; Hemorrhage; Endometrial Neoplasms; Intraoperative Complications; Uterine Cervical Neoplasms | Details | |
| Prothrombin complex concentrat (Taibang Biological Products) | Approved | Shandong Taibang Biological Products Co Ltd | Mainland China | Hemorrhage | Shandong Taibang Biological Products Co Ltd | 2014-09-30 | Hemorrhage; Antithrombin III Deficiency | Details | ||
| Antithrombin III (Human, Grifols) | Approved | Grifols Sa | Thrombate III | United States | Thromboembolism; Antithrombin III Deficiency | null | 1991-12-30 | Liver Cirrhosis; Coronavirus Disease 2019 (COVID-19); Thromboembolism; Antithrombin III Deficiency; Venous Thrombosis; Postoperative Complications | Details | |
| Andexanet alfa | PRT-44545; PRT-064445; PRT-4445 | Approved | Portola Pharmaceuticals Inc | Ondexxya, Annexa-A, Andexxa, Annexa-R | Japan | Hemorrhage | Alexion Pharmaceuticals Inc | 2018-05-03 | Drug-Related Side Effects and Adverse Reactions; Hemorrhagic Disorders; Pain; Hemorrhage | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Human prothrombin complex (Lanzhou Lansheng Blood Products) | Phase 3 Clinical | Lanzhou Lansheng Blood Products Co Ltd | Hemophilia B | Details | |
| Human prothrombin complex concentrate (Sichuan Yuanda Shuyang Pharmaceutical) | Phase 3 Clinical | Sichuan Yuanda Shuyang Pharmaceutical Co Ltd | Blood Coagulation Disorders | Details | |
| Human prothrombin complex(Hunan Ziguang Huhan Nanyue Pharmaceutical) | Phase 3 Clinical | Hunan Ziguang Huhan Nanyue Pharmaceutical Co Ltd | Hemophilia B | Details | |
| VE-1902 | VE-1902; VE-01902 | Phase 1 Clinical | Verseon | Atrial Fibrillation | Details |
| Human prothrombin complex concentrate (Harbin Shiheng Bioengineering Pharmaceutical) | Phase 3 Clinical | Harbin Pacific Biopharmaceutical Co Ltd | Hemophilia B | Details | |
| Targeted NIF-hirulog hybrid (Shandong New Time Pharmaceutical) | rNIF-hirulog; TNHH | Clinical | Shandong New Time Pharmaceutical Co Ltd | Details | |
| Semuloparin sodium | AVE-5026 | Sanofi | Details | ||
| Odiparcil | IVA-336; SB-424323 | Abbvie Inc | Details | ||
| PF-05230907 | PF-5230907; PF-05230907; PF-907 | Pfizer Pharmaceuticals Ltd (China) | Details | ||
| Enoxaparin sodium biosimilar (Techdow) | Phase 3 Clinical | Shenzhen Techdow Pharmaceutical Co Ltd | Blood Coagulation Disorders; Coronavirus Disease 2019 (COVID-19); Pneumonia, Viral; Coronavirus Infections | Details | |
| HHT-120 | HHT-120 | Phase 1 Clinical | Shanghai Huahuituo Pharmaceutical Technology Co Ltd | Venous Thromboembolism | Details |
| Dabigatran etexilate tosylate (Huons) | RDG-17012 | Phase 3 Clinical | Huons Co Ltd | Postoperative Hemorrhage | Details |
| SAR-107375-E | SAR-107375-E; SAR-107375E | Phase 1 Clinical | Sanofi | Venous Thrombosis | Details |
| CU-06 | CU-06-EYE; CU-06-IBD; CU-061004; Sac-1004; CU-06-ONCO; CU-06-HAE; CU06-1004 | Phase 2 Clinical | Curacle Co Ltd | Myocardial Infarction; Neoplasms; Lung Diseases; Stroke; Diabetic macular oedema; Colitis, Ulcerative; Macular Degeneration; Angioedemas, Hereditary; Crohn Disease; Diabetic Retinopathy | Details |
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